2023诺贝尔生理学或医学奖揭晓！
2023诺贝尔生理学或医学奖揭晓！
keyanrenwoxing
聚焦于最新科技论文解读、DFT计算方法、科研趣事等。
北京时间2023年10月2日17:45左右，诺贝尔生理学或医学奖揭晓，获得此奖的是美国科学家 Katalin Karikó 和 Drew Weissman 。
因为他们发现了核苷碱基修饰，从而开发出了有效抗COVID-19的mRNA疫苗
【 关键论文 】
[1] Karikó, K., Buckstein, M., Ni, H. and Weissman, D. Suppression of RNA Recognition by Toll-like Receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity , 2005 , 23, 165–175.
[2] Karikó, K., Muramatsu, H., Welsh, F.A., Ludwig, J., Kato, H., Akira, S. and Weissman, D. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol. Ther. , 2008 , 16, 1833–1840.
[3] Anderson, B.R., Muramatsu, H., Nallagatla, S.R., Bevilacqua, P.C., Sansing, L.H., Weissman, D. and Karikó, K. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res ., 2010 , 38, 5884–5892.
来源：https://www.nobelprize.org/