作为一种主要影响老年人的痴呆症，血管性痴呆(VD)的特点是大脑供血改变，导致认知障碍。本研究的目的是通过冥想蛋白激酶A (PKA)-CREB信号通路，探讨环磷酸腺苷(cAMP)反应元件结合(CREB)1基因沉默对VD小鼠认知功能障碍的影响。
2018年5月3日，江苏师范大学郑元林、陆军及吴冬梅共同通讯在
Molecular Medicine
（IF=5.7）在线发表题为“
Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia
”的研究论文，该研究表明，CREB1基因沉默导致VD加重，这是由于抑制PKA-CREB信号通路导致的，从而加剧了认知功能障碍。
但是，在2023年8月7日，
该文章被撤回，主要原因是数据异常。
另外，国自然基金委
对吴冬梅、郑元林、陆军等发表的论文共通报了35篇文章，截至2023年8月10日，已经被撤回33篇文章（部分文章为非通报文章）
。
撤销吴冬梅国家自然科学基金项目“TRPV4介导软骨藻酸处理致小鼠认知缺陷的分子机制”（批准号81400902），
追回已拨资金，永久取消吴冬梅国家自然科学基金项目申请资格
（自2022年1月18日起），给予吴冬梅通报批评；决定依照《国家自然科学基金条例》第三十五条第四项，并参照《国家自然科学基金委员会监督委员会对科学基金工作中不端行为的处理办法（试行）》第十七条第三、四项，撤销郑元林国家自然科学基金项目“HDAC6激活HMGB1/RAGE信号轴介导Ⅱ型糖尿病小鼠认知缺陷的机制研究”（批准号81571055），追回已拨资金，
取消郑元林国家自然科学基金项目申请资格5年（2022年1月18日至2027年1月17日），给予郑元林通报批评
；决定参照《国家自然科学基金委员会监督委员会对科学基金工作中不端行为的处理办法（试行）》第十七条第三、四项，
取消陆军国家自然科学基金项目申请资格5年（2022年1月18日至2027年1月17日），给予陆军通报批评
。
经江苏师范大学学术委员会调查，发现图3、图4 C、图6、图7 C图像不符合要求，主编已撤回本文。江苏师范大学学术委员会要求本文作者提供原始实验记录和数据进行核实，但作者无法提供。因此，总编辑对本文的数据和结果的完整性失去了信心。
吴冬梅、郑元林、陆军合作的撤稿文章列表（截至2023年8月10日共计33篇）：
[1]Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia,Molecular Medicine；
[2]The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells,Biomedicine & Pharmacotherapy；
[3]Long noncoding RNA nuclear enriched abundant transcript 1 impacts cell proliferation, invasion, and migration of glioma through regulating miR-139-5p/ CDK6,Journal of Cellular Physiology；
[4]Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy,Cell Proliferation；
[5]Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9,Molecular Therapy: Nucleic Acids；
[6]The role of HOTAIR-induced downregulation of microRNA-126 and interleukin-13 in the development of bronchial hyperresponsiveness in neonates,Journal of Cellular Physiology；
[7]MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor. Cancer Biomarkers；
[8]PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma. Journal of Thoracic Disease；
[9]MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.Oncotarget；
[10]MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK. Oncotarget；
[11]Mechanism of MicroRNA-708 Targeting BAMBI in Cell Proliferation, Migration, and Apoptosis in Mice With Melanoma via the Wnt and TGF-β Signaling Pathways. Technology in Cancer Research & Treatment；
[12]Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry；
[13]Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. Cellular Physiology and Biochemistry；
[14]Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry；
[15]Micro-RNA-143 inhibits proliferation and promotes apoptosis of thymocytes by targeting CXCL13 in a myasthenia gravis mouse model. AJP Cell Physiology；
[16]MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. Journal of Cellular and Molecular Medicine；
[17]S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of Cellular and Molecular Medicine；
[18]Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy. Cell Proliferation；
[19]Protective effect of autophagy on endoplasmic reticulum stress induced apoptosis of alveolar epithelial cells in rat models of COPD. Bioscience Report；
[20]Down-regulation of XIAP enhances the radiosensitivity of esophageal cancer cells in vivo and in vitro. Bioscience Report；
[21]microRNA-136 inhibits proliferation and promotes apoptosis and radiosensitivity of cervical carcinoma through the NF-κB pathway by targeting E2F1. Life Sciences；
[22]Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sciences；
[23]Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Research Bulletin；
[24]Effect of microRNA-186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase-signal transducer and activator of transcription pathway in a rat model of Alzheimer’s disease. Journal of Cellular Biochemistry；
[25]MicroRNA-30d preserves pancreatic islet β-cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin-induced diabetes mellitus. Journal of Cellular Biochemistry；
[26]MicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway. Journal of Cellular Biochemistry；
[27]Protective effects of microRNA-431 against cerebral ischemia-reperfusion injury in rats by targeting the Rho/Rho-kinase signaling pathway. Journal of Cellular Biochemistry；
[28]LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. Journal of Cellular Biochemistry；
[29]Down-regulated long non-coding RNA ANRIL restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin-induced diabetic rats via the NF-κB signaling. Journal of Cellular Biochemistry；
[30]Effects of S100A12 gene silencing on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats through the ERK signaling pathway. Journal of Cellular Biochemistry；
[31]MicroRNA-381-induced down regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Journal of Cellular Biochemistry；
[32]Effects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. Journal of Cellular Biochemistry；
[33]MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. IUBMB Life.
https://molmed.biomedcentral.com/articles/10.1186/s10020-023-00708-4
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