Osteogenesis process of tricalcium phosphate ceramics in vivo

To investigate the osteogenesis of calcium phosphate ceramics, β-TCP ceramics were implanted into thecondyle femur of rabbits, and tetracycline was injected termly. Specimens were host at 1, 2, 3, 4, 5, 6 months af-ter implanted. The new bone formation and osteogenesis process were observed by the histomorphology, fluorescentmicroscope, SEM and EPMA. The results demonstrate that, osteogenesis is active, there are abundant osteoblastson the surface of osteoid, mesenchymal cell hyperplasia and incursion is found in materials after 1 month. After 2months, there is blood vessel formation and macrophage soakage within materials. Bone-island appears and connectsby bone-bridge after 3 months. β-TCP ceramics degrade and are dispersed by new formation bone. Woven boneturns into bone lamella by rebuilding and calcification. The materials entirely change their original shape and com-bines with bone tissue as a whole after 6 months. The typical structure of spongy bone forms. It is confirmed thatβ-TCP is a degradable biocompatible artificial bone material which can incorporating in life.