New Approach to the Synthesis of C-Glycosides

1Introduction C-glycosides are important carbohydrate mimetics and have gained considerable attention because of their attractive biological activities as pharmaceutical targets and their resistance to enzymatic degradation in vivo.Consequently, a large number of C-glycosides have been synthesized for their bioactivity investigation, and various synthetic methodologies have been developed[1,2]. As a continuation of the synthesis of novel C-glycoside derivatives using exo-glycals as the precursor[3,4], we wish to present herein new approaches to the synthesis of C-aryl aminoglycoside via the 1,3-dipolar cycloaddition (Scheme 1 ) and C-disaccharides by Suzuki cross-coupling reaction (Scheme 2), and the synthesis of dihydropyrimidinonyl (DHPM) glycoside by the three component Biginelli reaction[5] (Scheme 3).