Anti-Endotoxic Effects of Syringic Acid of Radix Isatidis

Summary: The anti-endotoxic effect of syringic acid (SA) isolated from Radisx Isatidis (Banlangen,BLG) was studied. SA was extracted and isolated from BLG and diluted into 1 % solution. The con-tent of SA-pretreated endotoxin (ET) was quantitatively determined using Limulus test. The abilityof fever induction of ET pretreated with SA was measured using endotoxin-induced fever test in rab-bits. The LPS-induced death in mice pretreated with and without SA was compared. Results showedthat after pretreatment with SA, 83.16 % of ET was destroyed, the ET-induced fever in rabbits re-lieved markedly and the LPS-induced death rate in mice dropped from 68 % to 20 %. It was con-cluded that SA isolated from BLG had anti-endotoxic effects.