An Approach to New Water-soluble Oligo(ethylene glycol) Camptothecin Analogues by 1,3-Dipolar Cycloa

Combined with an effective copper-catalyzed triazole-forming reaction, a series of novel camptothecin derivatives were synthesized. Incorporating oligo(ethylene glycol) chains into the derivatives enhanced their water-solubility when compared to the parent compound (up to 55-fold).