Mechanism of T cell regulation by microRNAs
- 期刊名字:癌症生物学与医学(英文版)
- 文件大小:
- 论文作者:Juan Liu,Chang-Ping Wu,Bin-Fen
- 作者单位:Department of Tumor Biological Treatment,Department of Immunology
- 更新时间:2023-02-26
- 下载次数:次
MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that can modulate target gene expression at post-transcriptional level and participate in cell proliferation, differentiation, and apoptosis. T cells have important functions in acquired immune response;miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development, proliferation, differentiation, and function. For instance, miR-181 family members function in progression by targeting Bcl2 and CD69, among others. MiR-17 to miR-92 clusters function by binding to CREB1, PTEN, and Bim. Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression, we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.
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