Improved Method for Lacosamide Synthesis with Chemoenzymatic Method

Lacosamide was prepared by chemical method coupled with enzymatic method.N-Acetyl-D,L-3-methoxy-alanine,derived from D,L-3-methoxy-alanine,was used in the resolution process catalyzed by immobilized Escherichia coli cells with aminoacylase(EC3.5.1.14) activity.N-Acetyl-D-3-methoxy-alanine and L-3-methoxy-alanine were obtained from the resolution system.Lacosamide was synthesized by the amidation of N-acetyl-D-3-methoxy-alanine with benzylamine.