Crystal Structure of Norfloxacin Methanol Solvate: C16H18FN3O3 CH3OH H2O

Norfloxacin methanol solvate (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid methanol solvate) has been prepared. The crystal and molecular struc- tures of the title compound, C16H18FN3O3·CH3OH·H2O, were determined by X-ray diffraction me- thod. The compound crystallizes in monoclinic, space group P21/c with a = 7.8660(16), b = 22.525 (5), c = 10.253(2)(A), β = 108.31°, Mr = 369.39, V = 1724.7(6) (A)3, Z = 4, Dc = 1.423 g/cm3, F(000) = 784, R = 0.0557 and wR = 0.1224. The TGA analysis indicates that it decomposes completely at 723.75 ℃.