Spectrophotometric Study on Some Amino Acid Drugs with Chloranil and its Analytical Application

The interaction between amino acid drugs, aminobutyric acid, carbocisteine and levodopa, with chloranil was studied spectrophotometrically. The conditions were investigated and optimized. The interaction obeyed Beer's law over the range of 0.2-8.7, 1.2-20 and 2-26.4 μg/mL for aminobutyric acid, carbocisteine and levodopa, respectively. The validity was compared with that by the official methods1,3,5 and the recovery studies of standard addition method, the result is satisfactory. The proposed method has been successfully applied to the determination of the above drugs in tablets.