Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(Ⅱ)

A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material,6-substituted-2-tetralone as intermediate and Ullmann reaction,Suzuki reaction and spiro-hydantoin hydrolysis as key steps.The structures of key intermediate and target compounds were confirmed by 1H NMR,13C NMR,IR and MS.Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.