Synthesis, Characterization and Antitumor Activity of Lanthanum(Ⅲ) Complex with Demethylcantharidate

A novel complex of lanthanum(Ⅲ) with demethylcantharidate group (DCA), Na[La(DCA)2(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, 1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na2DCA in vitro.