Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 (ICs0 = 3.7 μg/mL). The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.