Nano TiO2 as a heterogeneous catalyst in an efficient one-pot three-component Mannich synthesis of β

TiO2 nanoparticles (TiO2 NPs) worked as an efficient heterogeneous catalyst in a one-pot, three-component, and solvent free Mannich reaction; producing various β-aminocarbonyls in good yields, and with good stereoselectivities. The catalyst was easily separated from the reaction mixture and was recycled four times with no significant loss of its catalytic activity.