Improved Synthesis of Miriplatin

Miriplatin,a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma.An improvd synthetic route was designed and used to prepare the target compound.The intermediate Pt(C6H14N2)(Ⅰ)2 was synthesized from K2PtC14,KI and (1R,2R)-1,2-cyclohexanediamine,Pt(C6H14N2)(Ⅰ)2 was reacted with AgNO3 to prepare Pt(C6H14N2)(H2O)2(NO3)2 solution then was subsequently reacted with CH3(CH2)12COONa in n-butanol to give target compound with satisfied yield 8l％(based on Pt(C6H14N2)I2).The structure of the target compound was identified by elemental analysis,ESI-MS,FT-IR,1H-NMR,thermal analysis,the structure was consistent with the target compound.