First Total Synthesis of 6-Oxodendrolasinolide

An efficient total synthesis of 6-oxodendrolasinolide 1, a new farnesane-based homosesquiterpene lactone, starting from geraniol 2 through twelve steps is described. Our work involved two key steps: (1) regioselective alkylation of the anion of vinyldithian 5 with allylic chloride 31, (2) Corey's oxidative lactionization method2.