Synthesis and Antibacterial Activity of New Cephalosporin Compounds

Five new cephalosporin compounds were designed and synthesized, and the antibacterial activities were evaluated by the standard serial 2-fold agar dilution method in vitro.The results showed that the activities of the compounds Ⅰa and Ⅰb against ESBL E. coli and K.pneumoniae are comparable to those of Cefepime.